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Abstract Purpose of Review This review summarizes recent advances in the clinical applications of glucagon-like peptide-1 receptor agonists (GLP-1RAs) beyond their established role in glycemic control for type 2 diabetes (T2DM)

Weekly or daily dosing (by compound) delivers sustained receptor engagement

Patients may experience dehydration and malnutrition due to prolonged nausea and reduced appetite

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When specific GLP-1 RAs were evaluated compared to placebo and other antidiabetic drugs, liraglutide was found to increase risk of thyroid disorders by 37% and dulaglutide in similar comparisons increased risk by 96%