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Conclusion: The Future of Obesity and Diabetes Treatment Retatrutide's results across two separate programs 28.328.7% weight loss in TRIUMPH-1/4, and -2.0% HbA1c with 16.8% weight loss in TRANSCEND-T2D-1 represent a genuine advance for a single medication addressing both severe obesity and type 2 diabetes

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The objective of this review is to summarize the mechanism of action of incretin receptor agonists, their effects in the gastrointestinal tract, and implications in clinical practice, particularly in the practice of gastroenterology, endoscopy, and surgery.