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We look forward to working with Ascendis to explore the potential of the TransCon technology platform to reduce the dosing frequency of GLP-1 receptor agonists and other treatments for cardiometabolic diseases. According to Ascendis, TransCon is a drug development platform that uses advanced chemistry to overcome known challenges in developing therapeutics

Understanding Semaglutide and Its Mechanism for Weight Loss Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used primarily to manage type 2 diabetes and aid in weight loss for individuals who are obese or overweight

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In patients with AD, 6 months of liraglutide increased blood-brain glucose transfer (likely via GLUT upregulation) (73), and stabilized cerebral glucose metabolism on FDG-PET (74)

A similar study on those with diabetes did show a larger GLP-1 response, though only by about 15 percent