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When patients enquire about adding L-carnitine or other supplements to their diabetes regimen, clinicians typically consider several factors: Evidence base : Is there robust clinical evidence supporting the supplement's use for the intended purpose

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Hanaire, H

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"Water intake helps us to actually flush out our kidneys and helps us to flush out what we're actually losing when we're doing weight loss and GLP-1s

However, by replacing arginine with threonine, the ECL2 of GLP-2R is no longer able to dip into the receptor core and becomes distant from the N-terminal histidine of GLP-2