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Pharmaceutics 12 (6), 587 (2020)

Titration of peptide-antibody fusions or unlabelled anti-PCSK9 mAbs were prepared in assay buffer (1X PBS, 0.1% BSA and 0.4 M Potassium Fluoride) and transferred to 384-well assay plates

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Administration of liraglutide to normal and diabetic mice before inducing MI reduced cardiac rupture and infarct size, improved cardiac output, and modulated the expression of cardioprotective genes in the mouse heart, including Akt, GSK-3beta, PPARbeta-delta, NRF-2, and HO-1