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This month, scientists from Novo Nordisk, the company that makes Ozempic, presented data at an Alzheimers research conference showing that the compound in the drug had failed to slow the progression of early Alzheimers in two clinical trials
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Support for this hypothesis comes from the finding that, in ovariectomized rats, estradiol replacement enhances peripheral GLP-1 induced suppression on food intake (199, 200)

While the difference was not dramatic (~3 points, which is well below the minimally clinically important difference in the MDS-UPDRS-3 of around ~5 points), it appeared to remain after a 2-month washout period, intended to support the idea that, because the improvements remained after removal of the incretin, the difference should be a disease-modifying, rather than a symptomatic benefit

When functioning normally, cortisol helps mobilise energy stores during periods of stress by promoting gluconeogenesis (glucose production) in the liver, increasing protein breakdown, and facilitating lipolysis

These symptoms may signal a serious issue that needs prompt evaluation
