retatrutide trial news VisualAbstract: reduces body weight by 17.5% in patients with obesity Eli Lilly says next-generation weight

There is no universally accepted 1:1 conversion between GLP-1 RAs

Fernandes, T

If you are considering semaglutide as part of your weight-management strategy, mastering the proper injection technique is paramount

The terminology is contested, but the underlying observation is not: the metabolic deterioration of neurons, their diminishing capacity to produce and manage energy, appears to be an early and potentially modifiable feature of the disease process, not merely a downstream consequence of it

Instead of targeting individual mediators the way antihistamines do, they may help reduce mast cell activation more upstream, potentially dampening the downstream inflammatory cascade

Together, they can produce roughly a 2.1% A1c reduction compared to approximately 1.5% with either drug alone