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Postgrad Med J

S.SedoA

Retatrutide adds a third receptor axis: GCGR activation alongside both GLP-1R and GIPR engagement

10 Weight Management / Obesity We have already discussed how the GLP-1 hormone affects appetite, fullness and other metabolic processes

None of these pathways have a direct stimulatory effect on the central nervous system

These can include changes in bile delivery and side effects like diarrhea
