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Compared to WT receptor, GLP-1R V229A caused a significant decrease in basal insulin secretion under vehicle (11 mM glucose alone) conditions (Figure 8C), which resulted in significantly increased insulin secretion fold-responses to exendin-4 (Figure 8D)

By increasing insulin secretion and reducing glucagon production, semaglutide GLP-1 helps lower blood sugar levels, which can be monitored through regular blood tests

Severe obesity in children and adolescents: metabolic effects, assessment, and treatment

doi:10.1172/JCI116919 77

Recently, GLP-1 pills have been approved for the US and Canadian markets