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Abbreviations BBB Bloodbrain barrier CNS Central Nervous System GFAP Glial fibrillary acidic protein GLP-1R Glucagon-like peptide-1 receptor HFD Highfat diet IB4 Biotinylated isolectin B4 Iba-1 Ionized calciumbinding adaptor molecule-1 ND Normolipid diet NVU Neurovascular unit SAL Saline solution SEMA Semaglutide Author contributions VE wrote the main manuscript