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2 For a diagnosis to be made, it should include two of the three following: (i) hyperandrogenism, whether clinical or biochemical, (ii) ovulatory dysfunction (this also includes cases of regular cycles where anovulation is evaluated by measuring progesterone levels), and (iii) polycystic ovaries on ultrasound, the latter could be replaced by raised levels of anti-Mllerian hormone (AMH) in adults

Symptoms of Menkes include sparse and de-pigmented hair, seizures and developmental delays

Secretion of Exe4 peptide via gene knock-in in Hepa1-6 cells To achieve sustained Exe4 secretion, we targeted the Albumin ( Alb ) locus due to its hepatocyte-specific high expression levels, ensuring robust expression of the integrated scExe4 gene 9,33,34

Insert the needle at a 90-degree angle (straight in)
