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2018, doi: 10.1016/j.molmet.2018.09.009 Frayling et al., A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure, Cell Rep., vol

The topic also includes updated information about setmelanotide (IMCIVREE), which was approved for those with Bardet-Biedl syndrome, a rare genetic disorder

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By activating both GIP and GLP-1 receptors, tirzepatide enhances insulin secretion in a glucose-dependent manner, meaning it stimulates insulin release only when blood glucose levels are elevated

It is used together with a healthy diet and regular exercise to improve blood sugar levels
