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Together with Daniel Drucker's paper it shows that neither Semaglutide nor Tirzepatide are good drugs to treat CNS diseases, as they do not cross the blood-brain barrier in meaningful quantities

eGFR estimated glomerular filtration rate

Morning timing also aligns with your natural circadian rhythm of hunger hormones, which peak earlier in the day for most people

A few maintain around 25% of the weight long-term, but the majority regain the rest