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Thomas MK, Nikooienejad A, Bray R, Cui X, Wilson J, Duffin K, Milicevic Z, Haupt A, Robins DA (2021) Dual GIP and GLP-1 receptor agonist tirzepatide improves beta-cell function and insulin sensitivity in type 2 diabetes

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showed that individuals with higher composite genetic risk scores, especially those carrying HLA class II and DR4 haplotypes, were more likely to progress through successive preclinical stages toward overt diabetes

doi: 10.1093/ajhp/zxz179

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