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Significant weight loss and improved blood sugar control for many patients

3,130,219 GLP-1 also activates PKA and EPAC through a cAMP-dependent pathway

Saxenda is older, requires daily injections, and usually produces more modest weight loss, but it may still be appropriate for some patients

In animal studies, GLP-1 and its analogs reduced macrophage infiltration in blood vessels, and production of pro-inflammatory cytokines such as IL-6, IL-1, TNF-, and CRP

doi: 10.1056/NEJMe2312646 [DOI] [PubMed] [Google Scholar] 266

These agents enable sustained GLP-1 receptor engagement and thereby modulate appetite regulation, gastric emptying, and insulinglucagon signaling