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They have less appetite

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Treatment: Drug: Tirzepatide Drug: Mibavademab-Placebo TZP + MIBA then Tirzepatide-placebo (TZP-PBO) + MIBA [Group C] Participants will receive TZP SC and MIBA SC for 24 weeks followed by TZP-PBO SC and MIBA SC for 24 weeks

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Both drugs mimic the naturally occurring hormone GLP-1 to help regulate blood sugar and reduce cravings

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Test days on which a rat failed to meet the FR10 criterion were excluded from primary analyses of %appropriate responding, but response rate data were retained to capture potential deficits in overall responding

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