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Gut modulation based anti-diabetic effects of carboxymethylated wheat bran dietary fiber in high-fat diet/streptozotocin-induced diabetic mice and their potential mechanisms

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NICE has recommended the use of Semaglutide, also called Wegovy, to adults with a body mass index (BMI) of at least 35 and have at least one weight-related comorbidity such as diabetes or hypertension - but the medication can only be prescribed as part of an NHS specialist weight management service. Unfortunately, the UK has very few so-called Tier 3 weight management services and it is unclear how Wegovy could be prescribed in most parts of the UK

Diabetes 57:A164A164 Thorens B (1992) Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1

These results suggest the protective effect of GLP-1 is related to its ability to regulate proinflammatory cytokines

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