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Stanford Medicine

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In particular, increased plasma insulin concentrations stimulate the gonadotropin releasing hormone (GnRH) pulsatility and potentiate the LH-dependent effect on the ovarian theca cells, leading to the enhanced synthesis of androgens and to the arrest of pre-antral follicle development [13]

9 Notably, these agents have also led to a significant decrease in major cardiac events, regardless of their effect on blood glucose, indicating a dual benefit for both cardiac health and diabetes management

We anticipate around seven actual launches in the US by 2030 after risk-adjustment