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Lancet Diabetes Endocrinol 10(6):393406 Gault VA, McClean PL, Cassidy RS, Irwin N, Flatt PR (2007) Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets
Effect of subcutaneous semaglutide vs placebo as an adjunct to intensive behavioral therapy on body weight in adults with overweight or obesity: the step 3 randomized clinical trial

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Therefore, clinicians should focus on individualized risk assessment, transparent counseling, and shared decision-making to guide appropriate therapy
