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Eligible publications included systematic reviews, meta-analyses, randomized controlled trials, observational studies (cohort, cross-sectional, case-control), and case series

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Moreover, the presence of a deleterious GIPR gene variant (E354Q) was associated with reduced BMD, as assessed through DXA scans in a longitudinal study spanning a decade and involving 1,424 perimenopausal females, and an assessment of fractures registered over a 16-year period showed a 50% increase in fracture risk (Torekov et al., 2014)