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Estos compuestos se diferencian en sus propiedades farmacodinmicas y farmacocinticas, sin embargo, son similares en su eficacia hipoglicemiante, y todos se administran por va oral48,49

Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial The Lancet Diabetes & Endocrinology (2025) PubMed Retatrutide significantly reduced total body fat mass versus placebo and dulaglutide: -15.2% (4 mg), -26.1% (8 mg), -23.2% (12 mg) percent reduction from baseline

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In line with data reported for dulaglutide [33], the overall absorption of metformin was unchanged when co-administered with semaglutide, while the delayed gastric emptying resulted in a somewhat prolonged absorption, and thereby a slightly lowered C max