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GLP-1 reduces neuroinflammation and also affects centers in the brain that are responsible for impulse control and reward signaling there are many studies showing that we indeed have GLP-1 receptors in our brain

The fix: expect one to two weeks of adjustment after each dose increase

And body recomposition, including muscle preservation and fat loss, doesn't always register on the scale even when it's happening

The SURPASS-3 study was set up to investigate the efficacy and safety of tirzepatide versus a titration of the basal insulin degludec inadequately controlled by an oral therapy of T2D by metformin with or without an SGLT2 inhibitor comedication for 52 weeks (72)

Low insulin levels can increase electrolyte loss, leading to headaches, fatigue, and muscle cramps

doi: 10.1152/ajpendo.00143.2016 [DOI] [PMC free article] [PubMed] [Google Scholar] 40.Huang S, Wang Y, Gan X, et al