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In a Phase 3 trial, orforglipron demonstrated a reduction in HbA1c levels by up to 1.6% and an average weight loss of 16 pounds over 40 weeks

Individuals with T2DM taking tirzepatide, a dual GIP and GLP- 1 receptor agonist, experienced better weight loss and blood sugar control than patients taking GLP- 1 receptor agonism

This creates a flatter pharmacokinetic curve with lower peak levels and higher trough levels, potentially reducing the intensity of receptor desensitization at peak concentrations while maintaining more consistent receptor occupancy throughout the week

Always wait at least 10 seconds for the alcohol to evaporate completely before proceeding with the injection

Among its strengths is its status as the largest study to date that focuses on the association between GLP-1 RA usage and the risk of psychiatric outcomes in real-world scenarios

Albert SG, Wood EM, Ahir V