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Patoulias D., Doumas M., and Papadopoulos C., MetaAnalysis Assessing the Effect of Tirzepatide on the Risk for Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus, American Journal of Cardiology 173 (2022): 157158

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The most frequently reported side effects were gastrointestinal side effects of mild-moderate intensity and were transient over time

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Only one of the trials included in the systematic review used the next-generation GLP-1 agonist semaglutide to treat obesity in adolescents aged 1218 years, and none used the combined GLP-1 and glucose-dependent insulinotropic peptide agonist, tirzepatide