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It is interesting to note that the positive effect of tirzepatide on body weight is associated with a significant improvement in quality of life and physical performance [50] and is independent of sex [51], baseline body mass index (BMI) [52] and potential side effects, predominantly gastrointestinal [53]

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AOM semaglutide also showed its largest quarter-over-quarter percentage point increase since the start of the study period, a trend likely driven by approval of the oral formulation of Wegovy in late 2025