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Description
The guidelines warn, however, that GLP-1 receptor agonist therapy is not indicated for all patients and should be used with caution in patients with a history of significant gastrointestinal disease, such as a diagnosis of gastroparesis, due to a possible exacerbation of the condition with incretin mimetic therapy

These are often individuals taking Ozempic or Wegovy for weight loss who exhibit hair shedding
For individuals with PCOS or insulin resistance, the body may not respond as effectively to GLP-1 medications, leading to less noticeable results
While genetic predispositions do not predict your exact response to GLP-1 medication, they can help explain your baseline metabolic tendencies and may support a more informed conversation with your provider about whether GLP-1 therapy addresses your specific biological patterns

Tirzepatide is a once-weekly injectable that mimics two naturally occurring hormones in your body: GLP-1 (glucagon-like peptide-1) GIP (glucose-dependent insulinotropic polypeptide) Together, these hormones help regulate blood sugar, reduce appetite, and slow digestion so you feel fuller for longer

By February 2025 for semaglutide and March 2025 for tirzepatide, FDA declared both shortages resolved and transitional exemption windows ended
