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A comprehensive 2022 meta-analysis by Dicembrini et al

Reactive oxygen species can adversely affect many cellular structures and processes including nuclear DNA, mitochondrial dynamics and function, lipids, proteins, calcium homeostasis, cellular architecture, receptor trafficking and endocytosis, and energy homeostasis

Blood sugar regulation also improves measurably, which means increased energy and fewer afternoon crashes

These data highlight the potential consequences of delaying treatmenteither by lack of access or by patient or health care professional choiceon subsequent risk of cirrhosis complications

What is increasingly clear, and clinically underappreciated, is that gut microbiota (GM) dysbiosis plays a central upstream role in driving all four conditions simultaneously