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Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions

"GLP-1/GIP/glucagon receptor tri-agonism: the emerging paradigm in obesity pharmacotherapy." Endocrinology and Metabolism

Weight Loss and Obesity Treatment In addition to their role in managing type 2 diabetes, GLP-1 agonists have gained significant attention for their potential in promoting weight loss and treating obesity

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This includes individuals with: Diagnosed MASLD or MASH, where GLP-1 therapy may offer therapeutic benefits but requires monitoring Chronic viral hepatitis (hepatitis B or C), particularly if transaminases are elevated Autoimmune hepatitis or other inflammatory liver conditions Cirrhosis or advanced fibrosis, where specialist consultation may be appropriate despite generally not requiring dose adjustment History of drug-induced liver injury from other agents For these patients, baseline comprehensive liver assessmentincluding liver enzymes, synthetic function tests (albumin, INR), and potentially imaging or non-invasive fibrosis markers (such as FIB-4 or ELF)helps establish a reference point for monitoring treatment effects

Nimacimab blunts rebound following treatment with tirzepatide : There is significant weight regain when treatment with tirzepatide is ended