the last cigarette commercial Aired on TV 1/1/1971 You've Come a Long Way
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This is not an exhaustive list of specific chemical additives with pharmacological effects

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Using nicotine before age 25 damages the parts of the brain that control attention, learning, mood and impulse control

doi:10.1136/thorax.56.10.758 23
As a result, this exposure window is really, really important. San Francisco is not alone in addressing this issue

Chinese Intelligence : From a Party Outfit to Cyber Warriors (PDF), Vivekananda International Foundation "Moderate and Balanced Afghanistan: Imperative for Regional Security"
