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245 WiedermannU.WiltschkeC.JasinskaJ.KundiM.ZurbriggenR.Garner-SpitzerE.et al (2010)

The more you are exposed to nicotine, the more of it you will need to produce the desired effects

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Consistent with caffeine clearance assessment, the induction of CYP1A2 by cigarette smoking is reversible after cessation
Some focus on smoothness and simplicity, while others lean toward stronger body or value-focused bulk tobacco

By examining a number of smoking implements excavated from the Moundville complex in central Alabama, they uncovered traces of nicotine in a pipe from around 1685 BC
