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Over time, frequent e-cigarette use can also lead to tolerance, meaning you may need more nicotine to feel the same effect

In another p53-null HCC line, the cell growth of Hep3B cells can be inhibited by melatonin (a hormone for regulation of circadian rhythms), which can promote the expression of several proapoptotic target genes (p21 and BAX) of p53 146

Similar to wtp53, post-transcriptional modifications such as phosphorylation, acetylation and ubiquitination can also regulate the level of mutp53

American Journal of Hypertension

Cytochrome c binds to apoptotic peptidase-activating factor 1 (APAF-1) and this adaptor platform induces activation of the initiator caspase, caspase-9

Feng Z, Zhan M, Meng R, Wang X, Xu Q