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Note: The legal smoking and drinking age in the US is 21

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33 The creatinine-based eGFR (eGFR cr ) and the cystatin C-based eGFR (eGFR cys ) were calculated using the equations proposed by the Japanese Society of Nephrology 25, 26 as follows: The average eGFR (eGFR average ) comprised the mean of the creatinine- and cystatin C-based eGFRs

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The complete analytical workflow is presented in Supplementary file Figure 1

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