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Smoking can suppress the immune system, which could explain why there are higher rates of death by infection among smokers

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In a few predisposed patients, a drug metabolite may bind to proteins in the epidermis and trigger an immune response, leading to immunoallergic cutaneous adverse drug reaction

SHS-induced inflammatory stress, i.e., interleukin 1beta (IL-1beta), impairs thyroid function and iodine uptake

Since it's a shrub, you'll be hard-pressed to find anything besides shafts made of elder wood