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With regard to random misclassification of secondhand smoke exposures, there is an inherent degree of unavoidable measurement error in the exposure measures used in epidemiologic studies

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Tyndale and coworkers have demonstrated that administration of nicotine for 21 days to monkeys in vivo decreases CYP2A6 activity (nicotine metabolism) by downregulating CYP2A6 mRNA and protein in liver (Schoedel et al

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The North Atlantic World in the Seventeenth Century , 1974, p