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More recent research findings suggest that patients may smoke to alleviate some of the extrapyramidal side-effects of antipsychotic medications (Goff Reference Goff, Henderson and Amico1992)

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Pilot data suggest that patients receiving both varenicline and the nicotine patch are more likely to experience adverse effects (nausea, headache, vomiting, dizziness, dyspepsia, and fatigue) than are those receiving the patch alone
