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The Cox proportional hazard model was used to estimate the risk of metabolic syndrome associated with HTP use, with adjustment for age, sex (male/female), alcohol drinking status (number of drinks per week: 0, 15, 6), and exercise (days of high-intensity exercise per week: 0, 12, 34, 5), conventional cigarette use, and e-cigarette use

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Complex Physiological and Behavioral Effects Nicotine influences brain chemicals like dopamine and norepinephrine, which can alter food cravings and appetite