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Nicotine Tob Res (2021) 23(9):160710

In a report released ahead of World No Tobacco Day on Wednesday, WHO warned that the annual death toll of seven million people had jumped from four million at the turn of the century, making tobacco the world's single biggest cause of preventable death

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CONCLUSIONS Despite the well-known risks associated with cigarette smoking in CD, we require more sophisticated big data type studies to further elucidate the true relationship between smoking and disease pathways, while accounting for the several negative cofactors found in active smokers which cast significant uncertainty on the magnitude of the direct effect of smoking on disease pathophysiology