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Nicotine and the Brain Nicotine stimulates release of dopamine from nucleus accumbens (brain reward center) Dopamine enhances feelings of reward and pleasure Nicotine increases serotonin levels, mostly in the amygdala (brain emotional response center) Serotonin can relieve depression and anxiety Nicotine and the Brain Initial experience with smoking causes nausea, dizziness, and/or coughing in some individuals Initial experience with smoking causes pleasurable experiences in others (e.g., head rush, buzz, dizziness)

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