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Importantly, smoking cessation after a cancer diagnosis improves clinical outcomes ( what to implement, there is little published on how to implement and evaluate tobacco treatment programs in cancer care settings ( To address this gap in research-to-practice, the National Cancer Institute (NCI) dedicated Cancer Moonshot funding to enhance the capacity of NCI-Designated Comprehensive Cancer Centers to implement sustainable evidence-based tobacco treatment programs ( RE-AIM has been used previously to evaluate tobacco treatment programs in healthcare settings ( Cancer Center Cessation Initiative Pragmatic Re-aim Application The C3I funded 42 Cancer Centers from 28 states and the District of Columbia for 2 years to implement evidence-based tobacco treatment programs through a supplement to the Cancer Center Support Grant ( The C3I Coordinating Center, in collaboration with an expert panel of physicians, psychologists, and behavioral scientists with clinical and implementation expertise in smoking cessation for cancer patients, developed measures to evaluate progress amongst the C3I Centers

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