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25 Desensitization ligand-induced closure and unresponsiveness of the receptor is believed to play a role in tolerance and dependence: the symptoms of craving and withdrawal begin in smokers when desensitized 4 2 * nicotinic cholinergic receptors become responsive during periods of abstinence, such as nighttime sleep

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A Journey in Lineage and Profession Abraham Clark was born on February 15, 1726, and lived in Elizabethtown New Jersey, now Elizabeth, located approximately 7 miles from what is now Clark, situated across the river from Staten Island

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