tobacco harm reduction risk continuum of for Nicotine Containing Products (2018) — Global State of Understanding the Continuum of Risk
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Tobacco is unique because it is a legal substance that contains nicotine which is highly addictive and highly carcinogenic (cancer causing)

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Bupropion side effects include dry mouth and insomnia

Casey Laizure, a professor at the University of Tennessee's department of clinical pharmacy, told Insider

The average nicotine content of each pellet of the Tropical is 5mg per roll, most of this is not released