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28,29 , namely: (1) enacting a systematic review approach and data extraction following a pre-specified and standardized protocol

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( 5 ) There, it binds to nicotinic acetylcholine receptors, triggering the release of several neurotransmitters, including dopamine (feelings of reward and pleasure), norepinephrine (focus and alertness), acetylcholine (attention and memory), serotonin (mood and sleep), and beta-endorphone (pain reduction and mood elevation)

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