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T-cell marker CD3 and more specifically cytotoxic T-cell marker CD8 both showed a significant increase in LR/MyD88 / and LR/IKK / ( Supplementary Figure S7D, E ), possibly due to the fact that MyD88 and IKK are downstream to multiple TLRs and blocking them leads to a signaling response akin to the promotion of T-cell cytotoxicity, which is nicely supported by the observed mRNA expression levels of Gzmb in these cohorts

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Although he initially attempted to reduce the amount of cigarettes he smoked, he realised that simply cutting back on cigarettes wasn't going to suffice-he needed to quit completely

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