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The e-cigarette market value in four ASEAN countries (Indonesia, Malaysia, Philippines, and Vietnam) reached USD 581.5 million in 2019 and was projected to grow by 30% (to USD 756.7 million) in 2023

RYO-tobacco led the market with a share of 45.1% in 2021

Food and Drug Administration for treatment of tobacco dependence include bupropion (a non-nicotine therapy) and nicotine replacement therapies in the form of a gum, patch, nasal spray, inhaler, and lozenge

Based on these previous reports, we hypothesized that the mechanisms of BFs-associated alleviation of tobacco CCO was related to one or more of the following factors: inhibition in pathogen loads, amelioration in soil chemical characteristics, or shifts in rhizospheric microbial communities

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