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Melatonin ameliorates PM2.5-induced spermatogenesis disorder by preserving H3K9 methylation and SIRT3

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Content of carbonyl compounds (A) and polycyclic aromatic hydrocarbons (PAHs) (B) in aerosols produced by a cigarette, a heated tobacco product and an e-cigarette

Abbreviations AZA: 5-aza-2-deoxycytidine CBP: c-AMP response element binding protein CCAT1: colon cancer-associated transcript-1 COPD: chronic obstructive pulmonary disease COX2: cyclooxygenase-2 COX II: cytochrome C oxidase subunit II CS: cigarette smoke DNMT: DNA methyl transferase ERK: extracellular signal-regulated kinase EZH2: enhancer of zeste homolog 2 HAT: histone acetyltransferase HDAC: histone deacetylase HMT: histone methyltransferase HOTAIR: Hox transcript antisense intergenic RNA IB: inhibitory kappa B IL-1Ra: interleukin-1 receptor antagonist LCPAT1: lung cancer progressionassociation transcript 1 lncRNA: long non-coding RNA MAFbx: muscle atrophy F-box MALAT1: metastasis associated in lung adenocarcinoma transcript 1 MAPK: mitogen-activated protein kinase MSK: mitogen- and stress-activated kinase MUL1: mitochondrial E3 ubiquitin protein ligase 1 MuRF1: muscle ring finger-1 protein NF-B: nuclear factor kappa B NLRP3: Nod-like receptor protein 3 PPAR: peroxisome proliferator-activated receptor PRMT: protein arginine methyltransferase SCAL1: smoke and cancer-associated lncRNA1 SIRT: sirtuin TETs: Tet-eleven translocation proteins UPS: ubiquitinproteasome system USP: ubiquitin-specific protease References Lee J, Taneja V, Vassallo R

Electronic or e-cigarettes These deliver a puff of vaporised liquid containing nicotine, which simulates smoking without burning