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Participants were exposed to three different blinded doses of intranasally administered nicotine (0, 0.5, 1.0mg) across three separate fixed dose experimental sessions

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We suggest against using e-cigarettes for smoking cessation for most people because of uncertainty about unapproved products, long-term harms, and public health impacts, but recognize that this may be considered for people who have unsuccessfully attempted other interventions or express a strong preference.Interpretation:This guideline provides a menu of evidence-based options to support smoking cessation