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Acknowledgements We are grateful to the animal facilities (IBPS), Camille Robert and Paris Vision Institute AAV production facility for viral production and purification

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Ex vivo patch-clamp recordings of VTA DA neurons To verify the functional expression of the excitatory opsin CatCh and the inhibitory opsin Jaws, 1012 weeks-old male DAT iCRE mice were injected with the viruses described above