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Several studies have shown that current smokers have significantly lower levels of testosterone compared to non-smokers
Thus, it can be deduced that RAGE can bind the ligands stimulated by CS and further promote the expression of IL-33, then coordinate a series of inflammatory responses downstream of IL-33 to aggravate the airway damage in patients with asthma, which results in the airway remodeling aggravated finally 5,74,75
Chen X, Wolff L, Aeppli D, Guo Z, Luan WM, Baelum V, et al
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