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Although the number and variety of toxic constituents in e-cigarette vapor may be less than in conventional cigarette smoke, there is significant overlap
The BPRF can be interpreted as indicating that, even accounting for between-study heterogeneity and its uncertainty, the log(RR) across the studied smoking range is at least as high as the BPRF (or at least as low as the BPRF for a protective risk)

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Instead, they found that men smoking just one cig a day had almost half the risk of heart disease and just over 40 percent of the stroke risk that pack-a-day guys had
A., Wang, F., Wong, M

[19] During the early stages, a combination of perceived pleasure acting as positive reinforcement and desire to respond to social peer pressure may offset the unpleasant symptoms of initial use, which typically include nausea and coughing