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Rheumatic fever (a condition that can cause damage to the heart, nerves, skin, and joints) and post-streptococcal glomerulonephritis (a form of kidney inflammation) are rare complications of untreated strep throat

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In figure 4, the mortality rates that would be seen at ages 60-64 among those who stop at about age 60 had to be interpolated (half way between the smoker and non-smoker rates), as they could not be assessed directly (partly because of reverse causality and partly because in this study there was often a delay of a few years before the next questionnaire arrived and cessation could be reported)

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The sample size was calculated to be 130 according to the OpenEpi sample size calculator website, with a two-sided significance level (1-) of 0.95, 0.8 power, a ratio of exposed/unexposed of 0.6, and an assumed odds ratio of 3